MethylDetox Profile

More than 50% of your patients are affected by genetic mutations in the methylation pathway.1 Standard MTHFR genotyping only evaluates folic acid metabolism. The MethylDetox Profile makes it easy to understand the complicated methylation process by giving comprehensive insights into the functional status of the methylation pathway.

The MethylDetox Profile includes genetic markers involved in methylation and homocysteine metabolism provided in a detailed lab report with personalized commentary. Additionally, continued homocysteine testing enables easy monitoring of patient progress.

Genetic variations in this pathway are associated with elevated homocysteine levels, impaired methylation processes and limited detoxification capacity. 

 As a result, these SNPs (single nucleotide polymorphisms) may contribute to accelerated aging, certain chronic diseases like cardiovascular disease and neurodegenerative disorders, impaired gene-regulation, poor drug clearance, and impaired neurotransmitter metabolism. 

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Understanding Methionine and Homocysteine Balance

Methionine and homocysteine metabolism are areas of active scientific and medical investigation. In addition to the MTHFR gene, specific SNPs in other genes also affect individual methylation capacity and homocysteine levels. 

Methionine and homocysteine balance is important for optimal health. Homocysteine is resynthesized from the amino acid methionine. In general, amino acids are supplied from a balanced diet or supplementation. However, a certain amount of methionine is recycled for methylation in the methionine/ homocysteine pathway.

Therefore, the primary purpose of methionine/ homocysteine balance is to ensure proper methylation by donating methyl groups for:

  • DNA methylation (gene regulation)

  • Regulation of neurotransmitters (e.g. epinephrine, norepinephrine, and serotonin)

  • Detoxification of catecholamines from the environment

  • Drug clearance (phase II liver detoxification)

  • Homocysteine is also a precursor in the biosynthesis of L-cysteine for glutathione; glutathione is important for the detoxification of electrophilic compounds (metals).

Elevated serum homocysteine is a widely accepted marker for methionine/homocysteine imbalance, which is a genetically controlled process.

Elevated homocysteine levels can lead to accelerated aging, cardiovascular disease and neurodegenerative disorders among others.