CICA: Celiac, IBS, and Crohn’s Array

CICA: Celiac, IBS, and Crohn’s Array


The CICA is a comprehensive test array that analyzes genetic predisposition, detects specific antibodies, and measures potentially inflammatory cellular reactions all through one simple blood draw.

Celiac disease risk analysis is determined based on the presence or absence of the HLA-DQ genotypes. Both the DQ8 and DQ2.5 genotypes are tested in this array, with the DQ2.5 genotypes representing a much greater risk of celiac disease.

Four specific serum antibodies (DGP IgG/IgA and tTG IgG/IgA) are tested due to their high sensitivity and specificity for active celiac disease. The higher the antibody levels, the more likely untreated celiac disease is present.

Genetic markers, mutations in the ATG16L1 and NOD2 genes, associated with the Crohn’s disease are tested along with serologic markers for complete assessment.

Anti-Saccharomyces Cerevisiae Antibody (ASCA; IgG/IgA) are immune proteins that are frequently present in people who have Crohn’s disease. The presence of ASCA may also reflect increased intestinal inflammation and permeability, including an association with active Crohn’s disease.

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Find out if gluten is impacting your health

“Imagine gluten ingestion on a spectrum. At one end, you have people with celiac disease, who cannot tolerate one crumb of gluten in their diet. At the other end, you have the lucky people who can eat pizza, beer, pasta and cookies – and have no ill effects whatsoever. In the middle, there is a murky area of gluten reactions, including gluten sensitivity.” - Alessio Fasano, M.D., Mass. General Hospital.

The Celiac, IBS, and Crohn’s Array (CICA) evaluates your genetic risk for celiac disease, serum markers associated with active celiac disease process, and genetic serum markers associated with Crohn’s disease.

The CICA is designed to provide an accurate evaluation of GI tract function by gathering information from various pathways.

Optionally, it can be combined with the Alcat Test to evaluate innate immune cell responses to as many as 400 other foods (including gluten, gliadin, casein and whey) and substances for the most comprehensive assessment.